The tight gas reservoir in Dehui fault depression has poor physical properties and well-developed micro and nano pores and throats. Water lock phenomenon is common during fracturing process. The nano micro emulsion assisted fracturing fluid system used in the early stage has good effect but is with high cost. In order to solve the problem of water blocking damage in tight gas reservoir, the performance evaluation and optimization of the compound system of p-perfluorononenyloxy benzene sulfonate sodium, perfluorooctane sulfonyl polyoxyethylene ether alcohol and branched alkyl aryl sulfonate were carried out. A new nano water-proof lock surfactant was independently developed. The surface tension is less than 21mN/ m, the solution particle size is less than 100nm, the core water lock damage rate is 15.6%-18.7%, which is 5% lower than the previous similar products, and the cost is expected to reduce by 70%. Meanwhile, the fracturing of Well DS80-2 in Jilin oilfield shows that the flow back rate is 3.8% after gas breakthrough, the wellhead pressure is 18.3MPa, and the daily gas production is 8.5×104m3. It is the highest production well of the same thickness gas reservoir in the same block, and the effect is obvious. The successful field test of new nano water-proof surfactant provides technical support for efficient exploration and development of tight gas reservoir in Jilin Oilfield.